Niraparib CAS NO.1038915-60-4

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CAS number :1038915-60-4
English name :Niraparib
English alias :(S)-2-(4-(piperidin-3-yl)phenyl) -2h-indazole-7-carboxamide; MK - 482798.00%; Niraparib(MK-4827); CS-2299; iraparib; Niraparib; EOS-60867; NiChemicalbookraparibbase; MK4827(Niraparib); NiraparibUSP/EP/BP
CBNumber:CB82514860
Molecular formula :C19H20N4O
Molecular weight :320.39

Melting point :187-189°C Boiling point :463.6±45.0°C(Predicted)
Density :1.34 Storage conditions :2-8°C(protectfromlight)
Solubility :DMSO(SChemicalbooklightly),Methanol(Slightly)
Acidity coefficient (pKa):15.36±0.30(Predicted)
Form :Solid
Color :PaleYellowtoLightYellow

Nirah panitan (niraparib, commodity name Zejula) is developed by Tesaro company poly adenosine diphosphate ribose polymerase (PARP) polybosphateadenosineribosepolymerase, inhibitor, can inhibit DNA repair. Its active component is free alkali, stable composition is a molecule containing water of crystallization of p-toluene sulfonate (niraparibtosylaChemicalbooktemonohydrate) or hydrochloride (niraparibhydrochloride, The effective components in niraparibtosylatemonohydrate. And on March 27, 2017, the FDA approved the market, mainly for the treatment of recurrent epithelial ovarian cancer, fallopian tube cancer, primary peritoneal cancer, and maintenance therapy in adult patients who have fully or partially responded to platinum-based chemotherapy drugs.