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Erlotinib hydrochloride CAS NO.183319-69-9
- Min.Order: 1 Kilogram
- Payment Terms: L/C,T/T
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- Product Details
Keywords
- 4-Quinazolinamine,N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-, monohydrochloride (9CI)
- 6,7-Bis(2-methoxyethoxy)-4-(3-ethynylanilino)quinazoline hydrochloride
- CP358774
Quick Details
- ProName: Erlotinib hydrochloride
- CasNo: 183319-69-9
- Molecular Formula: C22H24ClN3O4
- Appearance: white powder
- Application: Second - or third-line treatment of lo...
- DeliveryTime: 2 months
- PackAge: fiber can
- Port: shanghai port
- ProductionCapacity: 200 Kilogram/Year
- Purity: 99%
- Storage: store at 2-8℃
- Transportation: air transport
- LimitNum: 1 Kilogram
- Related Substances: ≤0.1%
- Residue on Ignition: ≤0.1%
- Heavy Metal: ≤20ppm
- Valid Period: 2 years
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Details
CAS number :183319-69-9
English name :Erlotinibhydrochloride English alias :ERLOTINIBHCL; Tarceva; ErL; Erlotinib,HydrochlorideSalt; CS-491; OSI774; RG-1415; CP358774; NSC718781; ChemicalbookRO-0508231API
Molecular formula :C22H24ClN3O4
Molecular weight :429.9
Chemical properties Melting point :223-225°C
Storage conditions: Inertatmosphere Storeinfreezer, under - 20 ° C
Solubility SolubleinDMSO(upto18mg/mlwithwarming)
Acidity factor (pKa):pKa(25°):5.Chemicalbook42 Form :Yellowpowder.
Color :Whiteoroff-white
Stability Stablefor1yearfromdateofpurchaseassupplied. SolutionsinDMSOmaybestoredat - 20 ° forupto3months.
Erlotinib hydrochloride is a small molecule epidermal growth factor receptor tyrosine kinase reversible inhibitor, mainly used in the treatment of locally advanced or metastatic non-small cell lung cancer second or third line treatment and pancreatic cancer.
Erlotinib targets the epidermal growth factor receptor subtype (EGFR-TK) that reversibly and selectively acts on tyrosine kinase receptors. Its mechanism of action is to compete with substrates in the cell, inhibit EGFR-TK phosphorylation, block tumor cell signaling, inhibit tumor cell growth, and induce apoptosis. Clinical studies have shown that the drug has an inhibitory effect on a variety of tumors. Compared with traditional chemotherapy drugs, it has the advantages of less adverse reactions, better safety and tolerance.