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repsox CAS NO.446859-33-2
- Min.Order: 10 Gram
- Payment Terms: L/C,T/T
- Available Specifications:
- Product Details
Keywords
- 1,5-Naphthyridine, 2-[3-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]-
- Alk 5 Inhibitor II
- SJN 2511
Quick Details
- ProName: repsox
- CasNo: 446859-33-2
- Molecular Formula: C17H13N5
- Appearance: light yellow powder
- Application: RepSox have been used to transform inh...
- DeliveryTime: 2 month
- PackAge: fiber can
- Port: shanghai port
- ProductionCapacity: 10 Kilogram/Year
- Purity: 99%
- Storage: Store at +4°C
- Transportation: air transport
- LimitNum: 10 Gram
- Related Substances: ≤0.1%
- Residue on Ignition: ≤0.1%
- Heavy Metal: ≤20ppm
- Valid Period: 2 years
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Details
The common name :2-(3-(6-methylpyridine-2-yl) -1h-pyrazole-4-yl)-1, 5-naphthidine
The English name : RepSox
CAS number: 446859-33-2
Molecular weight: 287.319
Density: 1.3± 0.1g /cm3
Boiling point: 501.9±50.0 °C at 760 mmHg
Molecular formula: C17H13N5
Melting point: 195 °C
RepSox is a potent and selective inhibitor of the TGF-β type I receptor/ALK5 (IC50 values are 4 and 23 nM for TGF-β type I receptor autophosphorylation and binding respectively). RepSox is selective for TGF-β type I receptor over a range of kinases, including p38 MAPK, JNK1 and GSK3 (IC50 > 16 μM). Enhances the efficiency of cellular reprogramming; replaces Sox2 by inducing Nanog expression.
RepSox synthesized to Ancillary Material Grade also available.
For more information about how RepSox may be used, see our protocols: Highly Efficient Generation of CiPSCs from MEFs, Generation of β cells from hPSCs, Reprogramming MEFs into Skeletal Muscle Progenitors.